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Clalit Research Institute

In 2010, Clalit Health Services, Israel’s largest integrated provider-payer health system established the Clalit Research Institute. The Clalit Research Institute’s mission is to turn data into decision-making insights that can be translated into policies for transforming healthcare delivery and clinical practice.

For more than one hundred years, Clalit Health Services has been Israel’s leading and largest healthcare organization. Today it serves as a non-profit integrated care organization for over four million patients, which is more than half of the country’s population. With universal healthcare coverage in Israel, most Clalit members remain covered by the organization for their entire lives (>95% five year retention). Clalit owns and operates 1,500 primary care clinics and 14 hospitals, including 30% of Israel’s hospital acute care beds, and employs nearly 35,000 doctors, nurses, pharmacists, paramedics, technicians, and administrators.


A team discussion at a trading room

Data Driven Research

Clalit Innovation collaborates closely with Clalit's Research Institute


The Clalit Research Institute is a globally recognized research center for data science in healthcare. Integrating real world data and knowhow into innovative insights and digital health tools,

bringing together an international, multidisciplinary team of professionals in epidemiology, data science and medicine.

Data Driven Research

Clalit’s database encompasses 20 years of medical history developed from close to 7 Million patient records. The database covers information from diagnoses, hospitalizations, clinic visits, demographic and personal markers, labs, medications (ordered and fulfilled), medical procedures, and special registries. 


AutoML Infrastructure

Our strong infrastructure capabilities allow us to build and develop complete predictive models in a matter of weeks (rather than months that it can take without the infrastructure)


We have developed a generic platform using AI and data driven proactive, preventive interventions

Work Desk


  • Clinical Needs Assessment

Clalit Research Institute experts collaborate closely with leading clinicians, policy makers, and other stakeholders. Together the team identifies needs, designs feasible solutions, assesses and quantifies expected value, and helps design monitoring tools to ensure the effectiveness of interventions.

  • Population Health Epidemiology

The population-based data allows for the identification of trends in incidence, prevalence, severity and mortality of key health conditions. This type of long-term and ongoing surveillance for trends in both infectious and non-communicable diseases enables policy intervention and helps to guide local (as well as regional and global) policy and decision-making.

  • Real-World Effectiveness

As an innovation-driven organization and an early adopter of new therapeutic and diagnostic technologies, Clalit is uniquely poised to perform real-world follow-up and passive evaluation of interventions, as well as pharmaco-epidemiologic assessments. We employ multiple methods that control for population biases, to measure real-world effectiveness of medications, vaccines, or health care interventions

  • Causal Inference

Causal inference is one of the most basic and critical methods used at the Clalit Research Institute, as well as in the field of epidemiology as a whole. We combine years of experience in causal study designs, with state-of-the-art methods that adapt machine-learning tools to estimate causal effects. Much of this research-level work is done in close collaboration with international leaders in academia.



Genomic Research

Behavioural Research

Health Services Evaluation


Academic Collaboration


Harvard University

Stanford University

Berkeley University

Tel Aviv University


Ben Gurion University 


Clalit Research Institute has played a key role in global pandemic policy and decision-making, with over 20 high impact papers published during the pandemic that have shed light on the vaccine effectiveness, safety, side effects, impact on specific populations of interest, virus variants and the effectiveness of booster shots.


Risk stratification models developed for Clalit’s COVID care strategy and management were implemented to manage the prioritization of individuals to receive interventions. For example, the individuals classified as at the highest risk of severe disease according to the model received a personal phone call from the physician with advice on how to best manage the risk from Covid-19, whilst the lowest risk individuals received a generic SMS with advice. These models also have and continue to play a vital role in prioritization of individuals infected with coronavirus for the various treatments available (an extremely limited resource that is not available for all infected individuals).

Academic Collaborations
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