Question 1

2026

Accepted Answer

PDE5a Inhibition Restricts Cancer Metastasis by Disrupting NPC1-Mediated Cholesterol Trafficking Through a Non-canonical cGMP-Dependent Pathway.
Ariav Y, Hayek S, Cantore T, Sanghvi N, Adler LN, Darzi N, Pal LR, Crawford DR, Malleron T, Silverbeck J, Yardeni E, Hajaj E, Ben-Zeev E, Sinha S, Ziman S, Shlomai A, Malitsky S, Itkin M, Levin-Zaidman S, Goliand I, Goldman O, Tishler H, Brandis A, Mehlman T, Kuznetsov Y, Kozer N, Shamash K, Itzhaki E, Ben-Chaim Moskovits N, Ranmar D, Stemmer SM, Ben-Shachar S, Ruppin E, Erez A.Cancer Res. 2026 Jul 14. doi: 10.1158/0008-5472.CAN-26-1818. Online ahead of print.PMID: 42446922
 
Learning Normal Representations for Blood Biomarkers.
Shah AP, Li MM, Lal Y, Cohen S, Antwarg LF, Sanchez M, Diao JA, Patel CJ, Reis BY, Balicer RD, Dagan N, Manrai AK.ArXiv [Preprint]. 2026 May 18:arXiv:2605.18701v1.PMID: 42238069 Free PMC article. Preprint.

The effect of nurse care management on multimorbid patients' hospital utilization: a comparative-controlled trial and an exploratory cohort study.
Shadmi E, Tonkikh O, Low M, Key C, Netzer D, Molcho T, Giveon S, Boult C, Balicer RD.Nat Commun. 2026 May 15. doi: 10.1038/s41467-026-73104-1. Online ahead of print.PMID: 42140977 Free article.
 
Evaluating the Impact of ClinGen Variant Curation Expert Panel Criteria Specifications on Variant Interpretation across Multiple Genes.
Marek-Yagel D, Greenberg R, Naftali M, Ben-Shachar S, Isakov O.J Mol Diagn. 2026 Jun;28(6):493-503. doi: 10.1016/j.jmoldx.2026.03.007. Epub 2026 Apr 15.PMID: 41997480

Psychologically informed reminder messages for promoting BRCA1/2 carrier screening: evidence from a large-scale population-based study.
Mushkat T, Greenberg R, Isakov O, Hayek S, Raskas H, Ben-Shachar S, Berliner-Senderey A.Eur J Public Health. 2026 Mar 14;36(2):ckag044. doi: 10.1093/eurpub/ckag044.PMID: 41921970 Free PMC article.
Incorporation of clinical and molecular variant properties improves the performance of in silico pathogenicity prediction tools.
Isakov O, Ashwal-Fluss R, Marek-Yagel D, Sunyaev S, Ben-Shachar S.Genet Med. 2026 May;28(5):102557. doi: 10.1016/j.gim.2026.102557. Epub 2026 Mar 26.PMID: 41904679
Scaling medical AI across clinical contexts.
Li MM, Reis BY, Rodman A, Cai T, Dagan N, Balicer RD, Loscalzo J, Kohane IS, Zitnik M.Nat Med. 2026 Feb;32(2):439-448. doi: 10.1038/s41591-025-04184-7. Epub 2026 Feb 3.PMID: 41634392 Review.

SUPT16H-associated neurodevelopmental disorder and neurocristopathy: genetic and phenotypic spectrum.
Lee E, Sim S, Choi HJ, Liang EY, Le C, Bina R, Cohen R, George E, Kim SY, Bhat G, Falsey E, Sidlow R, Clinard K, Ben-Shachar S, England E, Menendez B, Herman I, Nielsen S, Punetha J, Bhola P, Hamm JA, Keeney MA, Sitzman N, Berger S, Mehta L, Conn AJ, Downie L, Ashfaq M, Northrup H, Bruel AL, Odent S, Szot JO, Martinez NN, Park S, Refkin J, Good JM, Maurer F, Le Caignec C, Coman DJ, Anderson E, Richards LJ, Dean RJ, Yang C, Choi C, Hwang BJ, Lee JS, Dobyns WB, Choi M, Sherr EH, Chae JH, Kee Y, Argilli E.Hum Mol Genet. 2026 Feb 23;35(4):ddag003. doi: 10.1093/hmg/ddag003.PMID: 41556401 Free PMC article.
 
Improved Immune Response Against Influenza A Viruses With Receipt of a Recombinant Influenza Vaccine in Healthcare Personnel With Prior Low Antibody Response to Egg-Based Influenza Vaccines, Israel, 2019-2020.
Sumner KM, Katz M, Hirsch A, Peretz A, Greenberg D, Martin ET, Truscon R, Edwards LJ, Grant L, Noble EK, Newes-Adeyi G, Dreiher J, Fry A, Flannery B, Azziz-Baumgartner E, Monto AS, Levine MZ, Thompson M, Balicer R, Fowlkes A.J Infect Dis. 2026 Apr 29;233(4):e1011-e1021. doi: 10.1093/infdis/jiaf605.PMID: 41330417 Clinical Trial.

Question 2

2025

Accepted Answer

Can we identify individuals at risk to develop multiple myeloma? A machine learning-based predictive model.
Mittelman M, Israel A, Oster HS, Leshchinsky M, Ben-Shlomo Y, Kepten E, Dolberg OJ, Balicer R, Shaham G. Br J Haematol. 
2025 Jun 16. doi: 10.1111/bjh.20136. Online ahead of print.
PMID: 40524461

Real-world impact of physical activity reward-driven digital app use on cardiometabolic and cardiovascular disease incidence.
Berliner Senderey A, Mushkat T, Hadass O, Carmeli D, Hayek S, Charpingnon ML, Jacobson E, Balicer RD.
Commun Med (Lond). 2025 Mar 27;5(1):94. doi: 10.1038/s43856-025-00792-z.
PMID: 40148551

Safety and effectiveness of MVA-BN vaccination against mpox in at-risk individuals in Germany (SEMVAc and TEMVAc): a combined prospective and retrospective cohort study.
Hillus D, Le NH, Tober-Lau P, Fietz AK, Hoffmann C, Stegherr R, Huang L, Baumgarten A, Voit F, Bickel M, Goldstein G, Wyen C, Stocker H, Wünsche T, Lee M, Schulbin H, Vallée M, Bohr U, Potthoff A, Cordes C, Isner C, Knox B, Carmona A, Stobäus N, Balicer R; SEMVAc Study Group; Kurth F, Sander LE.
Lancet Infect Dis. 2025 Jul;25(7):775-787. doi: 10.1016/S1473-3099(25)00018-0. Epub 2025 Mar 18.
PMID: 40118087

Correction to: Development and Validation of a Colorectal Cancer Prediction Model: A Nationwide Cohort‑Based Study.
Isakov O, Riesel D, Leshchinsky M, Shaham G, Reis BY, Keret D, Levi Z, Brenner B, Balicer R, Dagan N, Hayek S.
Dig Dis Sci. 2025 Mar;70(3):1250. doi: 10.1007/s10620-025-08902-6.
PMID: 39939456

Effectiveness of AZD7442 (Tixagevimab/Cilgavimab) for Pre-Exposure Prophylaxis Against COVID-19 Hospitalization in Israel During the Omicron Sub-Variant Time Period.
Hayek S, Levy J, Shaham G, Dagan N, Serby D, Duskin-Bitan H, Dube S, Ferreira C, Livnat I, Talarico C, Taylor S, Venkatesan S, Yarden A, Balicer RD, Netzer D, Peretz A.
Infect Dis Ther. 2025 Feb;14(2):433-445. doi: 10.1007/s40121-024-01100-3. Epub 2025 Jan 7.
PMID: 39762664

Prospective Evaluation of Machine Learning for Public Health Screening: Identifying Unknown Hepatitis C Carriers 
Authors: Noa Dagan, M.D., Ori Magen, M.D., Michael Leshchinsky, M.S., Maya Makov-Assif, Marc Lipsitch, Ben Y. Reis, Ph.D., Shlomit Yaron, M.D., Doron Netzer, M.D., and Ran D. Balicer,

Published January 25, 2024
NEJM AI 2024;1(2)
DOI: 10.1056/AIoa2300012
VOL. 1 NO. 2

Improved Immune Response Against Influenza A Viruses With Receipt of a Recombinant Influenza Vaccine in Healthcare Personnel With Prior Low Antibody Response to Egg-Based Influenza Vaccines, Israel, 2019-2020.
Sumner KM, Katz M, Hirsch A, Peretz A, Greenberg D, Martin ET, Truscon R, Edwards LJ, Grant L, Noble EK, Newes-Adeyi G, Dreiher J, Fry A, Flannery B, Azziz-Baumgartner E, Monto AS, Levine MZ, Thompson M, Balicer R, Fowlkes A.J Infect Dis. 2026 Apr 29;233(4):e1011-e1021. doi: 10.1093/infdis/jiaf605.PMID: 41330417 Clinical Trial.
 PMID: 41330417

Machine learning for predicting Crohn's disease from routine blood tests years before diagnosis: results from the epi-IIRN cohort.
Lev-Tzion R, Dolev AS, Yuval Bar-Asher S, Balicer R, Ben-Tov A, Zacay G, Matz E, Dotan I, Turner D, Lerner B.J Crohns Colitis. 2025 Sep 7;19(8):jjaf143. doi: 10.1093/ecco-jcc/jjaf143.
PMID: 40758473
 
The active cohort: a population-based smartphone intervention for health outcomes.
Senderey AB, Mushkat T, Hadass O, Carmeli D, Jacobson E, Doherty A, Bennett DA, Balicer RD, Hayek S.J Public Health (Oxf). 2025 Dec 1;47(4):765-772. doi: 10.1093/pubmed/fdaf090.
PMID: 40728569 Free PMC article.
 
Genetics first approach: Expanding the utility of genetic testing by nongeneticist physicians.
Greenberg R, Averbuch NS, Sagi-Dain L, Maya I, Shahar NR, Kropach-Gilad N, Mark-Yagel D, Balicer RD, Ben Shachar S.Genet Med. 2025 Oct;27(10):101530. doi: 10.1016/j.gim.2025.101530. Epub 2025 Jul 16.
PMID: 40682473
 
A scoping review and expert consensus on digital determinants of health.
van Kessel R, Seghers LE, Anderson M, Schutte NM, Monti G, Haig M, Schmidt J, Wharton G, Roman-Urrestarazu A, Larrain B, Sapanel Y, Stüwe L, Bourbonneux A, Yoon J, Lee M, Paccoud I, Borga L, Ndili N, Sutherland E, Görgens M, Weicken E, Coder M, de Fatima Marin H, Val E, Profili MC, Kosinska M, Browne CE, Marcelo A, Agarwal S, Mrazek MF, Eskandar H, Chestnov R, Smelyanskaya M, Källander K, Buttigieg S, Ramesh K, Holly L, Rys A, Azzopardi-Muscat N, de Barros J, Quintana Y, Spina A, Hyder AA, Labrique A, Kamel Boulos MN, Chen W, Agrawal A, Cho J, Klucken J, Prainsack B, Balicer R, Kickbusch I, Novillo-Ortiz D, Mossialos E.Bull World Health Organ. 2025 Feb 1;103(2):110-125H. doi: 10.2471/BLT.24.292057. Epub 2024 Oct 29.
PMID: 39882497 Free PMC article.
 
ClinVec: Unified Embeddings of Clinical Codes Enable Knowledge-Grounded AI in Medicine.
Johnson R, Gottlieb U, Shaham G, Eisen L, Waxman J, Devons-Sberro S, Ginder CR, Hong P, Sayeed R, Su X, Reis BY, Balicer RD, Dagan N, Zitnik M.medRxiv [Preprint]. 2025 May 7:2024.12.03.24318322. doi: 10.1101/2024.12.03.24318322.
PMID: 39677476 Free PMC article. Preprint.

Question 3

2024

Accepted Answer

Unified Clinical Vocabulary Embeddings for Advancing Precision Medicine.
Johnson R, Gottlieb U, Shaham G, Eisen L, Waxman J, Devons-Sberro S, Ginder CR, Hong P, Sayeed R, Reis BY, Balicer RD, Dagan N, Zitnik M.
medRxiv [Preprint]. 2024 Dec 10:2024.12.03.24318322. doi: 10.1101/2024.12.03.24318322.
PMID: 39677476

Trends of common laboratory biomarkers after SARS-CoV-2 infection.
Meirman TD, Shapira B, Balicer RD, Rokach L, Dagan N.
J Infect. 2024 Dec;89(6):106318. doi: 10.1016/j.jinf.2024.106318. Epub 2024 Oct 17.
PMID: 39423876

Randomised immunogenicity trial comparing 2019-2020 recombinant and egg-based influenza vaccines among frequently vaccinated healthcare personnel in Israel.
Fowlkes AL, Peretz A, Greenberg D, Hirsch A, Martin ET, Levine MZ, Edwards L, Radke S, Lauring AS, Ferdinands JM, Zhang C, Yoo YM, Dreiher J, Newes-Adeyi G, Azziz-Baumgartner E, Fry AM, Monto AS, Balicer R, Thompson MG, Katz MA.
Int J Infect Dis. 2024 Dec;149:107260. doi: 10.1016/j.ijid.2024.107260. Epub 2024 Oct 10.
PMID: 39395753 Clinical Trial.

Incidence of laboratory-confirmed influenza and RSV and associated presenteeism and absenteeism among healthcare personnel, Israel, influenza seasons 2016 to 2019.
Azziz-Baumgartner E, Hirsch A, Yoo YM, Peretz A, Greenberg D, Avni YS, Glatman-Freedman A, Mandelboim M, MacNeil A, Martin ET, Newes-Adeyi G, Thompson M, Monto AS, Balicer RD, Levine MZ, Katz MA.
Euro Surveill. 2024 Aug;29(31):2300580. doi: 10.2807/1560-7917.ES.2024.29.31.2300580.
PMID: 39092531

Assessing Real-World Data From Electronic Health Records for Health Technology Assessment: The SUITABILITY Checklist: A Good Practices Report of an ISPOR Task Force.
Fleurence RL, Kent S, Adamson B, Tcheng J, Balicer R, Ross JS, Haynes K, Muller P, Campbell J, Bouée-Benhamiche E, García Martí S, Ramsey S.
Value Health. 2024 Jun;27(6):692-701. doi: 10.1016/j.jval.2024.01.019.
PMID: 38871437

Implementation of AZD7442 (Tixagevimab/Cilgavimab) COVID-19 Pre-exposure Prophylaxis (PrEP) in the Largest Health Maintenance Organization in Israel: Real-world Uptake and Sociodemographic and Clinical Characteristics Across Immunocompromised Patient Groups.
Hayek S, Levy J, Shaham G, Dagan N, Serby D, Duskin-Bitan H, Yarden A, Ferreira C, Livnat I, Dube S, Taylor S, Venkatesan S, Balicer RD, Netzer D, Peretz A.
Infect Dis Ther. 2024 Jun;13(6):1379-1389. doi: 10.1007/s40121-024-00981-8. Epub 2024 May 10.
PMID: 38728006

Development and Validation of a Colorectal Cancer Prediction Model: A Nationwide Cohort-Based Study.
Isakov O, Riesel D, Leshchinsky M, Shaham G, Reis BY, Keret D, Levi Z, Brener B, Balicer R, Dagan N, Hayek 
Dig Dis Sci. 2024 Jul;69(7):2611-2620. doi: 10.1007/s10620-024-08427-4. Epub 2024 Apr 25.
PMID: 38662163

To do no harm - and the most good - with AI in health care.
Goldberg CB, Adams L, Blumenthal D, Brennan PF, Brown N, Butte AJ, Cheatham M, deBronkart D, Dixon J, Drazen J, Evans BJ, Hoffman SM, Holmes C, Lee P, Manrai AK, Omenn GS, Perlin JB, Ramoni R, Sapiro G, Sarkar R, Sood H, Vayena E, Kohane IS; RAISE Consortium.
Nat Med. 2024 Mar;30(3):623-627. doi: 10.1038/s41591-024-02853-7.
PMID: 38388841 No abstract available.

Longitudinal machine learning uncouples healthy aging factors from chronic disease risks.
Cohen NM, Lifshitz A, Jaschek R, Rinott E, Balicer R, Shlush LI, Barbash GI, Tanay A.
Nat Aging. 2024 Jan;4(1):129-144. doi: 10.1038/s43587-023-00536-5. Epub 2023 Dec 7.
PMID: 38062254

Question 4

2023

Accepted Answer

The impact of increased access to telemedicine‏,
Zeltzer, Dan, et al. "The impact of increased access to telemedicine." Journal of the European Economic Association (2023): jvad035.‏

Carrier screening program for BRCA1/BRCA2 pathogenic variants among Ashkenazi Jewish women in Israel: an observational study,
‏‏Greenberg, Rotem, et al. "Carrier screening program for BRCA1/BRCA2 pathogenic variants among Ashkenazi Jewish women in Israel: an observational study." Genetics in Medicine Open 1.1 (2023): 100824.‏

Prospective Evaluation of Machine Learning for Public Health Screening: Identifying Unknown Hepatitis C Carriers,
Dagan, Noa, et al. "Prospective Evaluation of Machine Learning for Public Health Screening: Identifying Unknown Hepatitis C Carriers." NEJM AI 1.2 (2024): AIoa2300012.

Adoption and utilization of device-assisted telemedicine,
Zeltzer, Dan, et al. "Adoption and utilization of device-assisted telemedicine." Journal of Health Economics 90 (2023): 102780.‏

Why is end-of-life spending so high? Evidence from cancer patients,
Zeltzer, Dan, et al. "Why is end-of-life spending so high? Evidence from cancer patients." The Review of Economics and Statistics 105.3 (2023): 511-527.‏
‏

‏

Question 5

2022

Accepted Answer

The role of models in the covid-19 pandemic.
Steinberg DM, Balicer RD, Benjamini Y, De-Leon H, Gazit D, Rossman H, Sprecher E.Isr J Health Policy Res. 2022 Oct 20;11(1):36. doi: 10.1186/s13584-022-00546-5.PMID: 36266704

Myocarditis after BNT162b2 Vaccination in Israeli Adolescents.
Witberg G, Magen O, Hoss S, Talmor-Barkan Y, Richter I, Wiessman M, Aviv Y, Grinberg T, Shiyovich A, Schamroth-Pravda N, Auster O, Dagan N, Birk E, Balicer R, Kornowski R.N Engl J Med. 2022 Nov 10;387(19):1816-1817. doi: 10.1056/NEJMc2207270. Epub 2022 Oct 19.PMID: 36260842

Lifetime risk, life expectancy, and years of life lost to type 2 diabetes in 23 high-income jurisdictions: a multinational, population-based study.
Tomic D, Morton JI, Chen L, Salim A, Gregg EW, Pavkov ME, Arffman M, Balicer R, Baviera M, Boersma-van Dam E, Brinks R, Carstensen B, Chan JCN, Cheng YJ, Fosse-Edorh S, Fuentes S, Gardiner H, Gulseth HL, Gurevicius R, Ha KH, Hoyer A, Jermendy G, Kautzky-Willer A, Keskimäki I, Kim DJ, Kiss Z, Klimek P, Leventer-Roberts M, Lin CY, Lopez-Doriga Ruiz P, Luk AOY, Ma S, Mata-Cases M, Mauricio D, McGurnaghan S, Imamura T, Paul SK, Peeters A, Pildava S, Porath A, Robitaille C, Roncaglioni MC, Sugiyama T, Wang KL, Wild SH, Yekutiel N, Shaw JE, Magliano DJ.Lancet Diabetes Endocrinol. 2022 Nov;10(11):795-803. doi: 10.1016/S2213-8587(22)00252-2. Epub 2022 Sep 29.PMID: 36183736

BNT162b2 vaccine effectiveness in chronic kidney disease patients-an observational study.
Bielopolski D, Libresco G, Barda N, Dagan N, Steinmetz T, Yahav D, Charytan DM, Balicer RD, Rozen-Zvi B.Clin Kidney J. 2022 Jul 4;15(10):1838-1846. doi: 10.1093/ckj/sfac166. eCollection 2022 Oct.PMID: 36147707

Myocarditis following COVID-19 vaccine: incidence, presentation, diagnosis, pathophysiology, therapy, and outcomes put into perspective. A clinical consensus document supported by the Heart Failure Association of the European Society of Cardiology (ESC) and the ESC Working Group on Myocardial and Pericardial Diseases.
Heidecker B, Dagan N, Balicer R, Eriksson U, Rosano G, Coats A, Tschöpe C, Kelle S, Poland GA, Frustaci A, Klingel K, Martin P, Hare JM, Cooper LT, Pantazis A, Imazio M, Prasad S, Lüscher TF.Eur J Heart Fail. 2022 Nov;24(11):2000-2018. doi: 10.1002/ejhf.2669. Epub 2022 Oct 6.PMID: 36065751

Nirmatrelvir Use and Severe Covid-19 Outcomes during the Omicron Surge.
Arbel R, Wolff Sagy Y, Hoshen M, Battat E, Lavie G, Sergienko R, Friger M, Waxman JG, Dagan N, Balicer R, Ben-Shlomo Y, Peretz A, Yaron S, Serby D, Hammerman A, Netzer D.N Engl J Med. 2022 Sep 1;387(9):790-798. doi: 10.1056/NEJMoa2204919. Epub 2022 Aug 24.PMID: 36001529

Effectiveness of REGEN-COV antibody combination in preventing severe COVID-19 outcomes.Hayek S, Ben-Shlomo Y, Dagan N, Reis BY, Barda N, Kepten E, Roitman A, Shapira S, Yaron S, Balicer RD, Netzer D, Peretz A.Nat Commun. 2022 Aug 2;13(1):4480. doi: 10.1038/s41467-022-32253-9.PMID: 35918340

BNT162b2 Vaccine Effectiveness against Omicron in Children 5 to 11 Years of Age.
Cohen-Stavi CJ, Magen O, Barda N, Yaron S, Peretz A, Netzer D, Giaquinto C, Judd A, Leibovici L, Hernán MA, Lipsitch M, Reis BY, Balicer RD, Dagan N.N Engl J Med. 2022 Jul 21;387(3):227-236. doi: 10.1056/NEJMoa2205011. Epub 2022 Jun 29.PMID: 35767475

Association of opioid use disorder with healthcare utilization and cost in a public health system.Miron O, Barda N, Balicer R, Kor A, Lev-Ran S.Addiction. 2022 Nov;117(11):2880-2886. doi: 10.1111/add.15963. Epub 2022 Jun 12.PMID: 35638374

Association of Renin-Angiotensin-Aldosterone Inhibitors with COVID-19 Infection and Disease Severity among Individuals with Hypertension.
Mahanaimy M, Finkel U, Barda N, Rottman E, Balicer R, Berliner Senderey A, Feldman B.Isr Med Assoc J. 2022 May;24(5):310-316.PMID: 35598055

Comparing COVID-19-related hospitalization rates among individuals with infection-induced and vaccine-induced immunity in Israel.
Waxman JG, Makov-Assif M, Reis BY, Netzer D, Balicer RD, Dagan N, Barda N.Nat Commun. 2022 Apr 22;13(1):2202. doi: 10.1038/s41467-022-29858-5.PMID: 35459237

Short-term Adverse Events After the Third Dose of the BNT162b2 mRNA COVID-19 Vaccine in Adults 60 Years or Older.
Auster O, Finkel U, Dagan N, Barda N, Laufer A, Balicer RD, Ben-Shachar S.JAMA Netw Open. 2022 Apr 1;5(4):e227657. doi: 10.1001/jamanetworkopen.2022.7657.PMID: 35435973

Fourth Dose of BNT162b2 mRNA Covid-19 Vaccine in a Nationwide Setting.
Magen O, Waxman JG, Makov-Assif M, Vered R, Dicker D, Hernán MA, Lipsitch M, Reis BY, Balicer RD, Dagan N.N Engl J Med. 2022 Apr 28;386(17):1603-1614. doi: 10.1056/NEJMoa2201688. Epub 2022 Apr 13.PMID: 35417631

Pre- and Perinatal Factors Predicting Inflammatory Bowel Disease: A Population-Based Study with Fifty Years of Follow-Up.
Velosa M, Hochner H, Yerushalmi B, Harel S, Friss C, Calderon-Margalit R, Paltiel O, Manor O, Balicer RD, Greenfeld S, Kariv R, Ledderman N, Matz E, Peter I, Friedlander Y, Turner D.J Crohns Colitis. 2022 Sep 8;16(9):1397-1404. doi: 10.1093/ecco-jcc/jjac043.PMID: 35299254

Improving Cardiovascular Disease Prediction Using Automated Coronary Artery Calcium Scoring from Existing Chest CTs.
Barda N, Dagan N, Stemmer A, Yuval J, Bachmat E, Elnekave E, Balicer R.J Digit Imaging. 2022 Aug;35(4):962-969. doi: 10.1007/s10278-021-00575-7. Epub 2022 Mar 16.PMID: 35296940

Perianal Crohn Disease Is More Common in Children and Is Associated With Complicated Disease Course Despite Higher Utilization of Biologics: A Population-based Study From The epidemiology group of the Israeli IBD Research Nucleus (epiIIRN).
Atia O, Focht G, Lujan R, Ledder O, Greenfeld S, Kariv R, Dotan I, Yanai H, Gabay H, Balicer R, Haklai Z, Nevo D, Turner D.J Pediatr Gastroenterol Nutr. 2022 Jun 1;74(6):788-793. doi: 10.1097/MPG.0000000000003422. Epub 2022 Feb 22.PMID: 35192577

Indirect protection of children from SARS-CoV-2 infection through parental vaccination.
Hayek S, Shaham G, Ben-Shlomo Y, Kepten E, Dagan N, Nevo D, Lipsitch M, Reis BY, Balicer RD, Barda N.Science. 2022 Mar 11;375(6585):1155-1159. doi: 10.1126/science.abm3087. Epub 2022 Jan 27.PMID: 35084938

Validation of Heart Failure-Specific Risk Equations in 1.3 Million Israeli Adults and Usefulness of Combining Ambulatory and Hospitalization Data from a Large Integrated Health Care Organization.
Khan SS, Barda N, Greenland P, Dagan N, Lloyd-Jones DM, Balicer R, Rasmussen-Torvik LJ.Am J Cardiol. 2022 Apr 1;168:105-109. doi: 10.1016/j.amjcard.2021.12.017. Epub 2022 Jan 12.PMID: 35031113

Trends in all-cause mortality among people with diagnosed diabetes in high-income settings: a multicountry analysis of aggregate data.
Magliano DJ, Chen L, Carstensen B, Gregg EW, Pavkov ME, Salim A, Andes LJ, Balicer R, Baviera M, Chan JCN, Cheng YJ, Gardiner H, Gulseth HL, Gurevicius R, Ha KH, Jermendy G, Kim DJ, Kiss Z, Leventer-Roberts M, Lin CY, Luk AOY, Ma S, Mata-Cases M, Mauricio D, Nichols GA, Pildava S, Porath A, Read SH, Robitaille C, Roncaglioni MC, Lopez-Doriga Ruiz P, Wang KL, Wild SH, Yekutiel N, Shaw JE.Lancet Diabetes Endocrinol. 2022 Feb;10(2):112-119. doi: 10.1016/S2213-8587(21)00327-2. Epub 2022 Jan 10.PMID: 35026157

Early effectiveness of BNT162b2 Covid-19 vaccine in preventing SARS-CoV-2 infection in healthcare personnel in six Israeli hospitals (CoVEHPI).
Katz MA, Harlev EB, Chazan B, Chowers M, Greenberg D, Peretz A, Tshori S, Levy J, Yacobi M, Hirsch A, Amichay D, Weinberger R, Dor AB, Taraday EK, Reznik D, Chayat CB, Sagas D, Zvi HB, Berdinstein R, Rashid G, Avni YS, Mandelboim M, Zuckerman N, Rainy N, Akriv A, Dagan N, Kepten E, Barda N, Balicer RD.Vaccine. 2022 Jan 24;40(3):512-520. doi: 10.1016/j.vaccine.2021.11.092. Epub 2021 Dec 10.PMID: 34903372

Question 6

2021

Accepted Answer

Krause PR, Fleming TR, Longini IM, Peto R, Briand S, Heymann DL, Beral V, Snape MD, Rees H, Ropero AM, Balicer RD, Cramer JP, Muñoz-Fontela C, Gruber M, Gaspar R, Singh JA, Subbarao K, Van Kerkhove MD, Swaminathan S, Ryan MJ, Henao-Restrepo AM. SARS-CoV-2 Variants and Vaccines. New England Journal of Medicine, 2021. 385(2): pp. 179-186.
Cohen NM, Schwartzman O, Jaschek R, Lifshitz A, Hoichman M, Balicer R, Shlush LI, Barbash G, Tanay A. Personalized lab test models to quantify disease potentials in healthy individuals. Nature Medicine, 2021. 27(9): pp. 1582-1591.
Katz GM, Born KB, Balicer RD, Salmon A, Barrett K, Bell CM, Choi Y, Desveaux L, Evans GA, Hopkins J, Maltsev A, McGeer A, Morris AM, Perkhun A, Razak F, Rochon PA, Schwartz B, Slutsky AS, Watts T, Jüni P, Stall NM, on behalf of the Ontario COVID-19 Science Advisory Table. Lessons Learned from Israel’s Reopening During a Nationwide COVID-19 Vaccination Campaign. Science Briefs of the Ontario COVID-19 Science Advisory Table, 2021. 2(33).
Arnson Y, Senderey AB, Hoshen M, Reges O, Balicer R, Alnsasra H, Leibowitz M, Tsadok MA, Haim M. Identifying patients with atrial fibrillation with a single CHA2DS2-VASC risk factor who are at higher risk of stroke. Irish Journal of Medical Science, 2021. [ePub ahead of print]
Atia O, Asayag N, Focht G, Lujan R, Ledder O, Greenfeld S, Kariv R, Dotan I, Gabay H, Balicer R, Haklai Z, Nevo D, Turner D. Perianal Crohn’s Disease Is Associated With Poor Disease Outcome: A Nationwide Study From the epiIIRN Cohort. Clinical Gastroenterology Hepatology, 2021. [ePub ahead of print]
Stulman MY, Asayag N, Focht G, Brufman I, Cahan A, Ledderman N, Matz E, Chowers Y, Eliakim R, Ben-Horin S, Odes S, Dotan I, Balicer RD, Benchimol EI, Turner D. Epidemiology of Inflammatory Bowel Diseases in Israel: A Nationwide Epi-Israeli IBD Research Nucleus Study. Inflammatory Bowel Diseases, 2021. 27(11): pp. 1784-1794.
Avrahamy H, Shoval G, Hoshen M, Balicer RD, Kamhi-Nesher S, Zalsman G, Weizman A, Krivoy A. Association between Adherence to SSRI Treatment and Mortality among Individuals with Metabolic Syndrome Components. Pharmacopsychiatry, 2021. 54(5): pp. 232-239.
Balicer RD, Ohana R. Israel’s COVID-19 endgame. Science, 2021. 372(6543): p. 663.
Assa A, Assayag N, Balicer RD, Gabay H, Greenfeld S, Kariv R, Ledderman N, Matz E, Dotan I, Ledder O, Yerushalmy-Feler A, Turner D, Cohen S. Pediatric-onset Inflammatory Bowel Disease Has Only a Modest Effect on Final Growth: A Report From the epi-IIRN. Journal of Pediatric Gastroenterology and Nutrition, 2021. 73(2): pp. 223-230.
Lurie I, Shoval G, Hoshen M, Balicer R, Weiser M, Weizman A, Krivoy A. The association of medical resource utilization with physical morbidity and premature mortality among patients with schizophrenia: An historical prospective population cohort study. Schizophrenia Research, 2021. 237: pp. 62-68.
Berliner Senderey A, Ohana R, Perchik S, Erev I, Balicer RD. Encouraging uptake of the COVID-19 vaccine through 2 behaviorally informed interventions: National randomized field 3 experiment evidence from Israel. Behavioral Science and Policy, 2021. [ePub ahead of print]
Miron O, Barda N, Balicer R, Kor A, Lev-Ran S. Association of opioid use disorder with healthcare utilization and cost in a public health system. medRxiv, 2021.
Irving SA, Ball SW, Booth SM, Regan AK, Naleway AL, Buchan SA, Katz MA, Effler PV, Svenson LW, Kwong JC, Feldman BS, Klein NP, Chung H, Simmonds K, for the PREVENT study team. A multi-country investigation of influenza vaccine coverage in pregnant individuals, 2010–2016. Vaccine, 2021. 39(52): pp. 7598-7605.
Leader A, Dagan N, Barda N, Goldberg I, Raanani P, Spectre G, Balicer R, Gafter-Gvili A. Previously undiagnosed cancer in patients with arterial thrombotic events – A population-based cohort study. Journal of Thrombosis and Haemostasis, 2021. [ePub ahead of print]
Mittelman M, Magen O, Barda N, Dagan N, Oster HS, Leader A, Ohana R, Balicer R. Effectiveness of the BNT162b2mRNA Covid-19 Vaccine in Patients with Hematological Neoplasms. Blood, 2021. [ePub ahead of print]
Flaks-Manov N, Shadmi E, Yahalom R, Perry-Mezre H, Balicer RD, Srulovici E. Identification of elderly patients at risk for 30-day readmission: Clinical insight beyond big data prediction. Journal of Nursing Management, 2021. [ePub ahead of print]
Kickbusch I, Piselli D, Agrawal A, Balicer R, Banner O, Adelhardt M, Capobianco E, Fabian C, Singh Gill A, Lupton D, Medhora RP, Ndili N, Ryś A, Sambuli N, Settle D, Swaminathan S, Vega Morales J, Wolpert M, Wyckoff AW, Xue L, on behalf of the Secretariat of the Lancet and Financial Times Commission. The Lancet and Financial Times Commission on governing health futures 2030: growing up in a digital world. Lancet, 3021. 398(10312): pp. 1727-1776.
Makov-Assif M, Krispin S, Ben-Shlomo Y, Holander T, Dagan N, Balicer R, Barda N. The association between real-time reverse transcriptase polymerase chain reaction cycle threshold values, symptoms and disease severity among COVID-19 patients in the community: A retrospective cohort study. Infectious Diseases, 2021. ePub ahead of print.
Witberg G, Barda N, Hoss S, Richter I, Wiessman M, Aviv Y, Grinberg T, Auster O, Dagan N, Balicer RD, Kornowski R. Myocarditis after Covid-19 Vaccination in a Large Health Care Organization. New England Journal of Medicine, 2021. 385(23): pp. 2132-2139.
Katz MA, Bron Harlev E, Chazan B, Chowers M, Greenberg D, Peretz A, Tshori S, Levy J, Yacobi M, Hirsch A, Amichay D, Weinberger R, Ben Dor A, Keren Taraday E, Reznik D, Barazani Chayat C, Sagas D, Ben Zvi H, Berdinstein R, Rashid G, Shemer Avni Y, Mandelboim M, Zuckerman N, Rainy N, Akriv A, Dagan N, Kepten E, Barda N, Balicer RD. Early Effectiveness of BNT162b2 Covid-19 Vaccine in Preventing SARS-CoV-2 Infection in Healthcare Personnel in six Israeli Hospitals (CoVEHPI). Vaccine, 2021. [ePub ahead of print]
Barda N, Dagan N, Cohen C, Hernán MA, Lipsitch M, Kohane IS, Reis BY, Balicer RD. Effectiveness of a third dose of the BNT162b2 mRNA COVID-19 vaccine for preventing severe outcomes in Israel: an observational study. The Lancet, 2021. 398(10316): p. 2093-2100.
Dagan N, Barda N, Balicer RD. Adverse Effects after BNT162b2 Vaccine and SARS-CoV-2 Infection, According to Age and Sex. New England Journal of Medicine, 2021. 385(24): p. 2299.
Reis BY, Barda N, Leshchinsky M, Kepten E, Hernán MA, Lipsitch M, Dagan N, Balicer RD. Effectiveness of BNT162b2 Vaccine against Delta Variant in Adolescents. New England Journal of Medicine, 2021. 385(22): pp. 2101-2103.
Dagan N, Barda N, Biron-Shental T, Makov-Assif M, Key C, Kohane IS, Hernán MA, Lipsitch M, Hernandez-Diaz S, Reis BY, Balicer RD. Effectiveness of the BNT162b2 mRNA COVID-19 vaccine in pregnancy. Nature Medicine, 2021. 27(10): pp. 1693-1695.
Barda N, Dagan N, Ben-Shlomo Y,  Kepten E, Waxman J, Ohana R, Hernán MA, Lipsitch MA, Kohane IA, Netzer D, Reis BY, Balicer RD. Safety of the BNT162b2 mRNA Covid-19 Vaccine in a Nationwide Setting. New England Journal of Medicine, 2021. 385: pp. 1078-1090.
Kustin T, Harel N, Finkel U, Perchik S, Harari S, Tahor M, Caspi I, Levy R, Leschinsky M, Ken Dror S, Bergerzon G, Gadban H, Gadban F, Eliassian E, Shimron O, Saleh L, Ben-Zvi H, Amichay D, Ben-Dor A, Sagas A, Strauss M,  Shemer Avni Y, Huppert A, Kepten E, Balicer RD, Nezer D, Ben-Shachar S, Stern A. Evidence for increased breakthrough rates of SARS-CoV-2 variants of concern in BNT162b2 mRNA vaccinated individuals. Nature Medicine, 2021. 27(8): pp. 1379-1384.
Gur-Arie R, Katz MA, Hirsch A, Greenberg D, Malosh R, Newes-Adeyi g G, Davidovitch N, Rosenthal A. ‘‘You Have to Die Not to Come to Work”: A Mixed Methods Study of Attitudes and Behaviors regarding Presenteeism, Absenteeism and Influenza Vaccination among Healthcare Personnel with Respiratory Illness in Israel, 2016–2019. Vaccine, 2021. 39(17): pp. 2366-2374.
Magliano DJ, Chen L, Islam RM, Carstensen B, Gregg EW, Pavkov ME, Andes LJ, Balicer R, Baviera M, Boersma-van Dam E, Booth GL, Cha JCN, Xian Chua Y, Fosse-Edorh S, Fuentes S, Gulseth HL, Gurevicius R, Hwa Ha K, Hird TR, Jermendy G, Khalangot MD, Jung Kim D, Kiss Z, Kravchenko VI, Leventer-Roberts M, Lin CY, Luk AOY, Mata-Cases M, Mauricio D, Nichols GA, Nielen MM, Pang D, Paul SJ, Pelletier C, Pildava S, Porath A, Read SH, Carla Roncaglioni M, Lopez-Doriga Ruiz P, Shestakova M, Vikulova O, Wang KL, Wild SH, Yekutiel N, Shaw JE. Trends in the incidence of diagnosed diabetes: a multicountry analysis of aggregate data from 22 million diagnoses in high-income and middle-income settings. The Lancet Diabetes and Endocrinology, 2021. 9(4): pp. 203-211.
Shoer S, Karady T, Keshet A, Shilo S, Rossman H, Gavrieli A, Meir T, Lavon A, Kolobkov D, Kalka I, Godneva A, Cohen O, Kariv A, Hoch O, Zer-Aviv M, Castel N, Sudre C, Zohar AE, Irony A, Spector T, Geiger B, Hizi D, Shalev V, Balicer R, Segal E. A Prediction Model to Prioritize Individuals for a SARS-CoV-2 Test Built from National Symptom Surveys. Med (NY), 2021. 2(2): pp. 196-208.e4.
Dagan N, Barda N, Kepten E, Miron O, Perchik S, Katz MA, Hernán MA, Lipsitch M, Reis B, Balicer RD. BNT162b2 mRNA Covid-19 Vaccine in a Nationwide Mass Vaccination Setting. New England Journal of Medicine, 2021. 384(15): pp. 1412-1423.
Rossman H, Shilo S, Barbash-Hazan S, Shalom Artzi N, Hadar E, Balicer RD, Feldman B, Wiznitzer A, Segal E. Prediction of Childhood obesity from nationwide health records. The Journal of Pediatrics, 2021. 233: pp. 132-140.e1.
Kezerle L, Avgil Tsadok M, Akriv A, Berliner Senderey A, Bachrach A, Leventer-Roberts M, Haim M. Pre-Diabetes Increases Stroke Risk in Patients With Nonvalvular Atrial Fibrillation. JACC, 2021. 77(7): pp. 875–884.
Shepshelovich D, Barda N, Goldvaser H, Dagan N, Zer A, Diker-Cohen T, Balicer R, Gafter-Gvili A. Incidence of lung cancer following pneumonia in smokers: a population-based study. QJM, 2021. [ePub ahead of print]
Cohen-Stavi CJ, Giveon S, Key C, Molcho T, Balicer R, Shadmi E. Guideline deviation and its association with specific chronic diseases among patients with multimorbidity: a cross-sectional cohort study in a care management setting. BMJ Open, 2021. 11(1): p. e040961.
Reges O, Dicker D, Lundegaard Haase C, Finer N, Karpati T, Leibowitz M, Satylganova A, Feldman B. Body Mass Index Trajectories among People with Obesity and Association with Mortality: Evidence from a Large Israeli Database. Obesity Science and Practice, 2021. [Online ahead of print]
Dicker D, Greenland P, Leibowitz M, Hoshen, Berliner Senderey A, Rasmussen-Torvik LJ, Balicer RD, Reges O. All-Cause Mortality of Patients With and Without Diabetes Following Bariatric Surgery: Comparison to Non-surgical Matched Patients. Obesity Surgery, 2021. 31(2): pp. 755-762.
Benderly M, Buber J, Kalter-Leibovici O, Blieden L, Dadashev A, Lorber A, Nir A, Yalonetsky S, Chodick G, Weitzman D, Balicer R, Mazor Dray E, Murad H, Razon Y, Hirsch R, Israeli Adult Congenital Heart Disease Research Group. Health Service Utilization Patterns among Adults with Congenital Heart Disease: A Population-Based Study. Journal of the American Heart Association, 2021. 10(2): p. e018037.
Douglas LC, Leventer-Roberts M, Levinkron O, Wilson KM. Elective caesarean section and bronchiolitis hospitalization: A retrospective cohort study. Pediatric Allergy and Immunology, 2021. 32(2): pp. 280-287.
Omelchenko A, Hornik-Lurie T, Gabay H, Minha S, Assali A, Pereg D. LDL Cholesterol and ischemic stroke in patients with non-valvular atrial fibrillation. Diabetes/Metabolism Research and Reviews, 2021. 134(4): pp. 507-513.
Zeltzer D, Einav L, Chasid A, Balicer RD. Supply-Side Variation in the Use of Emergency Departments. Journal of Health Economics, 2021. 78: p. 102453.
Hayek S, Ben-Shlomo Y, Balicer R, Byrne K, Katz M, Kepten E, Raz I, Roitman E, Zychma M, Barda N. Pre-infection glycemic control and disease severity among patients with type 2 diabetes and COVID-19: A retrospective, cohort study. Diabetes, Obesity and Metabolism, 2021. 23(8): pp. 1995-2000.
Zeltzer D, Einav L, Finkelstein A, Shir T, Stemmer SM, Balicer RD. Why is End-of-Life Spending so High? Evidence from Cancer Patients. Review of Economics and Statistics, 2021.
Ben Shachar S, Barda N, Manor S, Israeli S, Dagan N, Carmi S, Balicer R, Zisser B, Louzoun Y. MHC Haplotyping of SARS-CoV-2 patients: HLA subtypes are not associated with the presence and severity of Covid-19 in the Israeli population. Journal of Clinical Immunology, 2021. 41(6): pp. 1154-1161.
Thompson MG, Soto G, Peretz A, Newes-Adeyi G, Yoo YM, Hirsch A, Katz MA, Tinoco Y, Shemer Avni Y, Ticona E, Malosh R, Martin E, Matos E, Reynolds S, Wesley M, Ferdinands J, Cheung A, Levine M, Bravo E, Arriola CS, Ester Castillo M, Carlos Castro J, Dawood F, Greenberg D, Manuel Neyra Quijandría J, Azziz-Baumgartner E, Monto A, Balicer RD. Influenza vaccine effectiveness within prospective cohorts of healthcare personnel in Israel and Peru 2016–2019. Vaccine, 2021. 39(47): pp. 6956-6967.

Question 7

2020

Accepted Answer

Berliner Senderey A, Kornitzer T, Gabriella Lawrence, Zysman H, Hallak Y, Ariely D, Balicer R. It’s how you say it: Systematic A/B testing of digital messaging cut hospital no-show rates. PLoS One, 2020. 15(6): p. e0234817.
Dreiher D, Blagorazumnaya O, Balicer R, Dreiher J. National initiatives to promote quality of care and patient safety: achievements to date and challenges ahead. Israel Journal of Health Policy Research, 2020. 9(1): p. 62.
Elis A, Leventer-Roberts M, Bachrach A, Lieberman N, Durst R, Knobler H, Balicer R. The Characteristics of Patients with Possible Familial Hypercholesterolemia-Screening a Large Payer/ProviderHealthcare Delivery System. QJM, 2020. 113(6): pp. 411-417.
Shahar Gabay T, Chapal-Ilani N, Moskovitz Y, Biezuner T, Oron B, Brilon Y, Fridman-Dror A, Sabah R, Balicer R, Tanay A, Mendelson-Cohen N, Dann EJ, Fineman R, Kaushansky N, Yehudai-Reshef S, Zuckerman T, Shlush LI. Donor cell leukemia: reappearance of gene mutations in donor cells – more than an incidental phenomenon? Haematologica, 2020. 105(12): pp. 2861-2863.
Leventer-Roberts M, Lev Bar-On R, Gofer I, Rosenbaum Z, Hoshen M, Feldman B, Balicer R. Choosing Wisely: Determining Performance of Unjustified Imaging in a Large Healthcare System. International Journal of Clinical Practice, 2020. 75(1): p. e13644.
Leventer-Roberts M, Cohen-Stavi C, Hoshen M, Gofer I, Sherf M, Balicer R. Analyzing Admission Rates for Multiple Ambulatory Care–Sensitive Conditions. The American Journal of Managed Care, 2020. 26(5): pp. e155-e161.
Segal E, Zhang F, Lin X, King G, Shalem O, Shilo S, Allen WE, Alquaddoomi F, Altae-Tran H, Anders S, Balicer R, Bauman T, Bonilla X, Booman G, Chan AT, Cohen O, Coletti S, Davidson N, Dor Y, Drew DA, Elemento O, Evans G, Ewels P, Gale J, Gavrieli A, Geiger B, Grad YH, Greene CS, Hajirasouliha I, Jerala R, Kahles A, Kallioniemi O, Keshet A, Kocarev L, Landua G, Meir T, Muller A, Nguyen LH, Oresic M, Ovchinnikova S, Peterson H, Prodanova J, Rajagopal J, Rätsch G, Rossman H, Rung J, Sboner A, Sigaras A, Spector T, Steinherz R, Stevens I, Vilo J, Wilmes P. Building an international consortium for tracking coronavirus health status. Nature Medicine, 2020. 26(8): pp. 1161-1165.
Rossman H, Keshet A, Shilo S, Gavrieli A, Bauman T, Cohen O, Shelly E, Balicer R, Geiger B, Dor Y, Segal E. A framework for identifying regional outbreak and spread of COVID-19 from one-minute population-wide surveys. Nature Medicine, 2020. 26(5): pp. 634-638.
Cohen-Stavi CJ, Key C, Giveond S, Molchoc T, Balicer RD, Shadmi E. Assessing guideline-concordant care for patients with multimorbidity treated in a care management setting. Family Practice, 2020. 37(4): pp. 479-485.
Guri A, Flaks-Manov N, Ghilai A, Hoshen M, Flidel Rimon O, Ciobotaro P, Zimhony O. Third-generation cephalosporin resistant Enterobacteriaceae in neonates and young infants: impact and outcome. The Journal of Maternal-Fetal & Neonatal Medicine, 2020. [Online ahead of print]
Lavie G, Hoshen M, Leibowitz M, Benis A, Akriv A, Balicer R, Reges O. Statin therapy for primary prevention in the elderly and its association with new-onset diabetes, cardiovascular events and all-cause mortality. The American Journal of Medicine, 2020. [Online ahead of print]
Leventer-Roberts M, Dagan N, Berent JM, Brufman I, Hoshen M, Braun M, Balicer RD, Feldman BS. Using population-level incidence of hepatitis C virus and immigration status for data-driven screening policies: a case study in Israel. Journal of Public Health, 2020. [Online ahead of print]
Hochman E, Feldman B, Weizman A, Krivoy, Gur S, Barzilay E, Gabay H, Levy J, Levinkron O, Lawrence G. Development and validation of a machine learning-based postpartum depression prediction model: a nationwide cohort study. Depression and Anxiety, 2020. pp. 1-12.
Rayyan-Assi H, Feldman B, Leventer-Roberts M, Akriv A, Raz I. The Relationship between Inpatient Hyperglycemia and Mortality is Modified by Baseline Glycemic Status. Diabetes/Metabolism Research and Reviews, 2020.
Cohen-Stavi C, Key C, Molcho T, Yacobi M, Balicer RD, Shadmi E. Mixed methods evaluation of reasons why care deviates from clinical guidelines among patients with multimorbidity. Medical Care Research and Review, 2020. [Epub ahead of print]
Barda N, Yona G, Rothblum GN, Greenland P, Leibowitz M, Balicer R, Bachmat E, Dagan N. Addressing bias in prediction models by improving subpopulation calibration. JAMIA, 2020. 28(3): pp. 549-558.
Miron, O, Zeltzer D, Shir T, Balicer RD, Einav L, Feldman BS. Rising Opioid Consumption among Non-Cancer and Non-Elderly Patients – Israel’s Alarming Example. Regional Anesthesia & Pain Medicine, 2020. 46(5): pp. 455-456.
Taub S, Hoshen M, Balicer R, Kamhi-Nesher S, Weizman A, Krivoy A. Metabolic predictors for mortality among patients treated with long-term clozapine – A longitudinal study. European Neuropsychopharmacology, 2020. 41: pp. 63-69.
Barda N, Riesel D, Akriv A, Levy J, Finkel U, Yona G, Greenfeld D, Sheiba S, Somer J, Bachmat E, Rothblum G, Shalit U, Netzer D, Balicer R, Dagan N. Developing a COVID-19 mortality risk prediction model when individual level data is not available. Nature Communications, 2020. 11(1): p. 4439.
Regan AK, Feldman B, Azziz-Baumgartner E, Naleway AL, Williams J, Wyant BE, Simmonds K, Effler PV, Booth S, Ball SW, Katz MA, Fink RV, Thompson MG, Chung H, Kwong JC, Fell DB. An international cohort study of birth outcomes associated with hospitalized acute respiratory infection during pregnancy. The Journal of Infection, 2020. 81(1):48-56.
Reges O, Leibowitz M, Hirsch A, Dicker D, Finer F, Lundegaard Haas, Satylganova A, Leventer-Roberts M, Feldman. A comprehensive descriptive assessment of obesity related chronic morbidity and estimated annual cost burden from a population-based electronic health record database. Israel Journal of Health Policy Research, 2020. 9(1): p. 32.
Feldman B, Orbach-Zinger S, Leventer-Roberts M, Hoshen M, Dagan N, Balicer R, Eidelman LA. Maternal age and cardiovascular and metabolic disease outcomes: A retrospective cohort study using data from population-based electronic medical records. The Journal of Maternal-Fetal & Neonatal Medicine, 2020. 33(11): pp. 1853-1860.
Arnson Y, Hoshen M, Berliner-Senderey A, Reges O, Balicer R, Leibowitz M, Avgil Tsadok M, Haim M. Risk of Stroke, Bleeding, and Death in Patients with Nonvalvular Atrial Fibrillation and Chronic Kidney Disease. Cardiology, 2020. 145(3): pp. 178-186.
Shadmi E, Zeltzer D, Shir T, Flaks-Manov N, Einav R, Balicer RD. Can Targeting High-Risk Patients Reduce Readmission Rates? Evidence from Israel. Journal of Applied Economics, 2020. 65(2): pp. 484-494.
Wesley MG, Soto G, Sofia Arriola C, Gonzales M, Newes‐Adeyi G, Romero C, Veguilla V, Levine MA, Silva M, Ferdinands JM, Dawood FS, Reynolds SB, Hirsch A, Katz M, Matos E, Ticona E, Castro J, Castillo M, Bravo E, Cheung A, Phadnis R, Toth Martin E, Tinoco Y, Manuel Neyra Quijandria J, Azziz‐Baumgartner E, Thompson MG, the VIP Cohort Study Working Group. Prospective cohort study of influenza vaccine effectiveness among healthcare personnel in Lima, Peru: Estudio Vacuna de Influenza Peru, 2016-2018. Influenza and Other Respiratory Viruses, 2020. 14(4): pp. 391-402.
Wang X, Li Y, O’Brien KL, Madhi SA, Widdowson MA, Byass P, Omer SB, Abbas Q, Ali A, Amu A, Azziz-Baumgartner E, Bassat Q, Brooks WA, Chaves SS, Chung A, Cohen C, Echavarria M, Fasce RA, Gentile A, Gordon A, Groome M, Heikkinen T, Hirve S, Jara JH, Katz MA, Khuri-Bulos N, Krishnan A, de Leon O, Lucero MG, McCracken JP, Mira-Iglesias A, Moïsi JC, Munywoki PK, Ourohiré M, Polack FP, Rahi M, Rasmussen ZA, Rath BA, Saha SK, Af Simões E, Sotomayor V, Thamthitiwat S, Treurnicht FK, Wamukoya M, Yoshida LM, Zar HJ, Campbell H, Nair H, Respiratory Virus Global Epidemiology Network. Global burden of respiratory infections associated with seasonal influenza in children under 5 years in 2018: a systematic review and modelling study. Lancet Global Health, 2020. 8(4): pp. e497-e510.
Guri A, Flaks-Manov N, Ghilai A, Hoshen M, Rimon OF, Ciobotaro P, Zimhony O. Risk factors for third-generation cephalosporin resistant Enterobacteriaceae in gestational urine cultures: A retrospective cohort study based on centralized electronic health records. PLoS One, 2020. 15(1): p. e0226515.
Flaks-Manov N, Srulovici E, Yahalom R, Perry-Mezre H, Balicer R, Shadmi E. Preventing hospital readmissions: healthcare providers’ perspectives on “impactibility” beyond EHR 30-day readmission risk prediction. Journal of General Internal Medicine, 2020. 35(5): pp.1484-1489.
Guz-Mark A, Feldman BS, Ghilai A, Hoshen M, Avner-Cohen H, Shkalim Zemer V, Assa A, Zevit N, Shamir R. High Rates of Serology Testing for Coeliac Disease, and Low Rates of Endoscopy in Serologically Positive Children and Adults in Israel. Lessons from a Large Real-World Database. European Journal of Gastroenterology and Hepatology, 2020. 32(3): pp. 329-334.
Dagan N, Elnekave E, Barda N, Bregman-Amitai O, Bar A, Orlovsky M, Bachmat E, Balicer RD. Automated opportunistic osteoporotic fracture risk assessment using computer tomography scans to aid in FRAX underutilization. Nature Medicine, 2020. 26(1): pp. 77-82.
Artzi NS, Shilo S, Hadar E, Rossman H, Barbash-Hazan S, Ben-Haroush A, Balicer RD, Feldman B, Wiznitzer A, Segal E. Prediction of gestational diabetes based on nationwide electronic health records. Nature Medicine, 2020. 26(1): pp. 71-76.
Barda N, Riesel D, Akriv A, Levi J, Finkel U, Yona G, Greenfeld D, Sheiba S, Somer J, Bachmat E, Rothblum GN, Shalit U, Netzer D, Balicer R, Dagan N. Performing risk stratification for COVID-19 when individual level data is not available, the experience of a large healthcare organization. Medrxiv, 2020.
Leventer-Roberts M, Gofer I, Barak Corren Y, Reis BY, Balicer R. Constructing data-derived family histories using electronic health records from a single healthcare delivery system. European Journal of Public Health, 2020. 30(2): pp. 212-218.
Dawood FW, Garg S, Fink RV, Russell ML, Regan AK, Katz MA, Booth S, Chung H, Klein NP, Kwong JC, Levy A, Naleway A, Risel D, Thompson MG, Wyant BE, Fell DB on behalf of the PREVENT workgroup. Epidemiology and clinical outcomes of hospitalizations for acute respiratory or febrile illness and laboratory-confirmed influenza among pregnant women during six influenza seasons, 2010-2016. The Journal of Infectious Diseases, 2020. 221(10): pp. 1703-1712.
Reges O, Weinberg H, Hoshen M, Greenland P, Rayyan-Assi H, Avgil Tsadok M, Bachrach A, Balicer R, Leibowitz M, Haim M. Combining Inpatient and Outpatient Data for Diagnosis of Non-Valvular Atrial Fibrillation Using Electronic Health Records: A Validation Study. Clinical Epidemiology, 2020. 12: pp. 477-483.
Srulovici E, Leventer-Roberts M, Curtis B, He X, Hoshen M, Rotem M, Reges O, Key C, Levin-Iaina N, Strizek A, Feldman B. Long-term effectiveness of the Diabetes Conversation Map™ Program on health outcomes: A case-control retrospective cohort study. Journal of Advanced Nursing, 2020. 76(9): pp. 2299-2310.
Kezerle L, Tsadok MA, Berliner Senderey A, Hoshen M, Leventer-Roberts M, Reges O, Leibowitz M, Haim M. Use of oral anticoagulation therapy in the first 3 months after the diagnosis of atrial fibrillation in Israel: A population-based study. Journal of Cardiovascular Electrophysiology, 2020. 31(6): pp. 1356-1363.
Kezerle L, Tsadok MA, Akriv A, Feldman B, Leventer-Roberts M, Ohana R, Haim M. Pre-diabetes a new risk factor for stroke in non-valvular atrial fibrillation. EP Europace, 2020.  22(Supplement 1).
Dagan N, Barda N, Riesel D, Grotto I, Sadetzki S, Balicer R. A score-based risk model for predicting severe COVID-19 infection as a key component of lockdown exit strategy. medRxiv, 2020.

Question 8

2019

Accepted Answer

Tsadok Avgil M, Streifler YJ, Benbenishty G, Man N, Balancer R, Makori A, Feldman SB, Gilutz H. Silent Brain Infarction: A Missed Opportunity for Prevention. Academia Journal of Stroke, 2019. 1(1): pp. 25-30.
Leventer-Roberts M, Haklai Z, Applbaum Y, Goldberger N, Cohen D, Levinkron O, Feldman B, Balicer R. Validating reported cause of death using integrated electronic health records from a nation-wide database. Journal of Public Health (Oxford), 2019.
Flaks-Manov N, Topaz M, Hoshen M, Balicer R, Shadmi E. Identifying patients at highest-risk: the best timing to apply a readmission predictive model. BMC Medical Informatics and Decision Making, 2019. 19(1): p. 118.
Barzilay R, Lawrence GM, Berliner A, Gur RE, Balicer R, Leventer-Roberts M, Weizman A, Feldman B. Association between prenatal exposure to a one-month period of repeated rocket attacks and neuropsychiatric outcomes up through age nine: A retrospective cohort study. European Child & Adolescent Psychiatry, 2019.
Levine H, Leventer-Roberts M, Hoshen M, Mei-Zahav M, Balicer R, Blau H. Healthcare utilization in infants and toddlers with asthma-like symptoms. Pediatric Pulmonology, 2019. 54(10): pp. 1567-1577.
Jaffe DH, Flaks-Manov N, Benis A, Gabay H, DiBonaventura M, Rosenbaum H, Joseph A, Bachrach A, Leventer-Roberts M. Population-based cohort of 500 patients with Gaucher disease in Israel. BMJ Open, 2019. 9(1): p. e024251.
Naleway AL, Ball S, Kwong JC, Wyant BE, Katz MA, Regan AK, Russell ML, Klein NP, Chung H, Simmonds KA, Azziz-Baumgartner E, Feldman BS, Levy A, Fell DB, Drews SJ, Garg S, Effler P, Barda N, Irving SA, Shifflett P, Jackson ML, Thompson MG. Estimating Vaccine Effectiveness Against Hospitalized Influenza During Pregnancy: Multicountry Protocol for a Retrospective Cohort Study. JMIR Research Protocols, 2019. 8(1): p. e11333.
Dagan N, Cohen-Stavi CJ, Avgil Tsadok M, Leibowitz M, Hoshen M, Karpati T, Akriv A, Gofer I, Gilutz H, Podjarny E, Bachmat E, Balicer RD. Translating clinical trial results into personalized recommendations by considering multiple outcomes and subjective views. NPJ Digital Medicine, 2019. 2: p. 81.
Gottesman BS, Low M, Almog R, Chowers M. Quinolone Consumption by Mothers Increases Their Children’s Risk of Acquiring Quinolone-Resistant Bacteriuria. Clinical Infectious Diseases, 2019.
Rasmussen-Torvik LJ, Reges O, Greenland P, Dicker D, Leibowitz M, Senderey AB, Hoshen M, Balicer RD. All-Cause Mortality Following Bariatric Surgery in Smokers and Non-smokers. Obesity Surgery, 2019. 29(12): pp. 3854-3859.
Witberg G, Plakht Y, Bental T, Feldman BS, Leventer-Roberts M, Levi A, Gabay H, Balicer R, Gerber Y, Kornowski R. Development of a risk score for predicting the benefit versus harm of extending dual antiplatelet therapy beyond 6 months following percutaneous coronary intervention for stable coronary artery disease. PLoS One, 2019. 14(2): p. e0209661.
Shoval G, Balicer RD, Feldman B, Hoshen M, Eger G, Weizman A, Zalsman G, Stubbs B, Golubchik P, Gordon B, Krivoy A. Adherence to antidepressant medications is associated with reduced premature mortality in patients with cancer: A nationwide cohort study. Depression and Anxiety, 2019. 36(10): pp. 921-929.
Low M, Neuberger A, Hooton TM, Green MS, Raz R, Balicer RD, Almog R. Association between urinary community-acquired fluoroquinolone-resistant Escherichia coli and neighbourhood antibiotic consumption: a population-based case-control study. The Lancet Infectious Diseases, 2019. 19(4): pp. 419-428.
Segaloff HE, Leventer-Roberts M, Riesel D, Malosh RE, Feldman BS, Shemer-Avni Y, Key C, Monto AS, Martin ET, Katz MA. Influenza Vaccine Effectiveness Against Hospitalization in Fully and Partially Vaccinated Children in Israel; 2015-16, 2016-17, and 2017-18. Clinical Infectious Diseases, 2019. 69(12): pp. 2153-2161.
Avgil Tsadok M, Berliner Senderey A, Reges O, Leibowitz M, Leventer-Roberts M, Hoshen M, Haim M. Comparison of stroke risk stratification scores for atrial fibrillation. The American Journal of Cardiology, 2019. 123(11): pp. 1828-1834.
Jaffe DH, Klein AB, Benis A, Flores NM, Gabay H, Morlock R, Teltsch DY, Chapnick J, Molad Y, Giveon SM, Feldman B, Leventer-Roberts M. Incident Gout and Chronic Kidney Disease: Healthcare Utilization and Survival. BMC Rheumatology, 2019. 3: p. 11.
Madjar N, Shlosberg D, Leventer-Roberts M, Akriv A, Ghilai A, Hoshen M, Krivoy A, Zalsman G, Shoval G. Childhood methylphenidate adherence as a predictor of antidepressants use during adolescence. European Child and Adolescent Psychiatry, 2019. 28(10): pp. 1365-1373.
Srulovici E, Leventer-Roberts M, Curtis B, He X, Hoshen M, Rotem M, Bachrach A, Reges O, Key C, Levin-Iaina N, Strizek A, Feldman B. Effectiveness of Managing Diabetes During Ramadan Conversation Map intervention: A difference-in-differences (self-comparison) design. International Journal of Nursing Studies, 2019. 95: pp. 65-72.
Zeltzer D, Balicer RD, Shir T, Flaks-Manov N, Einav L, Shadmi E. Prediction Accuracy with Electronic Medical Records versus Administrative Claims. Medical Care, 2019. 57(7): pp. 551-559.
Thompson MG, Kwong JC, Regan AK, Katz MA, Drews SJ, Azziz-Baumgartner E, Klein NP, Chung H, Effler PV, Feldman BS, Simmonds K, Wyant BE, Dawood FS, Jackson ML, Fell DB, Levy A, Barda N, Svenson LW, Fink RV, Ball SW, Naleway A; for the PREVENT Workgroup. Influenza Vaccine Effectiveness in Preventing Influenza-Associated Hospitalizations during Pregnancy: A Multi-Country Retrospective Test Negative Design Study, 2010-2016. Clinical Infectious Diseases, 2019. 68(9): pp. 1444-1453.
Kornilov E, Orbach-Zinger S, Hoshen M, Weiniger CF, Fein S, Fireman S, Firman S, Aviram A, Eidelman LA. A prospective observational study of the change in regional cerebral oxygen saturation during cesarean delivery in women receiving phenylephrine prophylaxis for spinal hypotension. International Journal of Obstetric Anesthesia, 2019. 37, pp. 29-35.

Question 9

2018

Accepted Answer

Orbach-Zinger S, Landau R, Harousch AB, Ovad O, Caspi L, Kornilov E, Ioscovich A, Bracco D, Davis A, Fireman S, Hoshen M, Eidelman LA. The relationship between women’s intention to request a labor epidural analgesia, actually delivering with labor epidural analgesia, and postpartum depression at 6 weeks: a prospective observational study. Anesthesia and Analgesia, 2018. 126(5): pp. 1590-1597.
Balicer RD, Luengo-Oroz M, Cohen-Stavi C, Loyola E, Mantingh F, Romanoff L, Galea G. Using big data for non-communicable disease surveillance. The Lancet Diabetes and Endocrinology, 2018. 6(8): pp. 595-598.
Reges O, Greenland P, Dicker D, Leibowitz M, Hoshen M, Gofer I, Rasmussen-Torvik LJ, Balicer RD. Association of Bariatric Surgery Using Laparoscopic Banding, Roux-en-Y Gastric Bypass, or Laparoscopic Sleeve Gastrectomy vs Usual Care Obesity Management With All-Cause Mortality. JAMA, 2018. 319(3): pp. 279-290.
Arnson Y, Hoshen M, Berliner Senderey A, Reges O, Balicer R, Leibowitz M, Avgil Tsadok M, Haim M. Comparing Management and Outcomes in Men and Women With Nonvalvular Atrial Fibrillation: Data From a Population-Based Cohort. JACC Clinical Electrophysiology, 2018. 4(5): pp. 604-614.
Spitzer-Shohat S, Shadmi E, Goldfracht M, Key C, Hoshen M, Balicer RD. Evaluating an organization-wide disparity reduction program: Understanding what works for whom and why. PLoS One, 2018. 13(3): e0193179.
Epstein D, Berger G, Barda N, Marcusohn E, Barak-Corren Y, Muhsen K, Balicer RD, Azzam ZS. The incidence of acute pulmonary embolism following syncope in anticoagulant-naïve patients: A retrospective cohort study. PLoS One, 2018. 13(3):e0193725.
Srulovici E, Garg V, Ghilai A, Feldman B, Hoshen M, Balicer RD, Skup M, Leventer-Roberts M. Is Patient Support Program Participation Associated with Longer Persistence and Improved Adherence Among New Users of Adalimumab? A Retrospective Cohort Study. Advances in Therapy, 2018. 35(5): pp. 655-665.
Friedman MY, Leventer-Roberts M, Rosenblum J, Zigman N, Goren I, Mourad V, Lederman N, Cohen N, Matz E, Dushnitzky DZ, Borovsky N, Hoshen MB, Focht G, Avitzour M, Shachar Y, Chowers Y, Eliakim R, Ben-Horin S, Odes S, Schwartz D, Dotan I, Israeli E, Levi Z, Benchimol EI, Balicer RD, Turner D, On behalf of the Israeli IBD Research Nucleus . Development and validation of novel algorithms to identify patients with inflammatory bowel diseases in Israel: an epi-IIRN group study. Clinical Epidemiology, 2018. 10: pp. 671–681.
Regan AK, Klein NP, Langley G, Drews SJ, Buchan S, Ball S, Kwong JC, Naleway A, Thompson M, Wyant BE, Levy A, Chung H, Feldman B, Katz M; PREVENT group. Respiratory Syncytial Virus Hospitalization during Pregnancy in Four High-income Countries, 2010-2016. Clinical Infectious Diseases, 2018. 67(12): pp. 1915-1918.
Shlezinger M, Amitai Y, Akriv A, Gabay H, Shechter M, Leventer-Roberts M. Association between exposure to desalinated sea water and ischemic heart disease, diabetes mellitus and colorectal cancer; A population-based study in Israel. Environmental Research, 2018. 166: pp. 620-627.
Srulovici E, Feldman B, Reges O, Hoshen M, Balicer RD, Rotem M, Shadmi E, Key C, Curtis B, He X, Rubin G, Strizek A, Leventer-Roberts M. Which patients with Type 2 diabetes will have greater compliance to participation in the Diabetes Conversation Map™ program? A retrospective cohort study. Diabetes Research and Clinical Practice, 2018. 143: pp. 337-347.
Cohen-Stavi CJ, Balicer RD, Leventer Roberts M. Innovation in health care for proactive care delivery and strategic clinical decision-making: integrating research, technology and practice. Public Health Panorama, 2018. 4(3): pp. 470-474.
Eisen A, Porter A, Hoshen M, Balicer RD, Reges O, Rabi Y, Leibowitz M, Iakobishvili Z, Hasdai D. The association between eGFR in the normal or mildly impaired range and incident cadiovascular disease: Age and sex analysis. European Journal of Internal Medicine, 2018. 54: pp. 70-75.
Alnsasra H, Haim M, Senderey AB, Reges O, Leventer-Roberts M, Arnson Y, Leibowitz M, Hoshen M, Avgil-Tsadok M. Net clinical benefit of anticoagulant treatments in elderly patients with nonvalvular atrial fibrillation: Experience from the real world. Heart Rhythm, 2018. 16(1): pp. 31-37.
Steinman MA, Low M, Balicer RD, Shadmi E. Impact of a nurse-based intervention on medication outcomes in vulnerable older adults. BMC Geriatrics, 2018. 18(1): p. 207.
Karpati T, Leventer-Roberts M, Feldman B, Cohen-Stavi C, Raz I, Balicer R. Patient Clusters Based on HbA1c Trajectories: a Step Toward Individualized Medicine in Type 2 Diabetes. PLoS One, 2018. 13(11): p. e0207096.
Hirsch A, Katz MA, Laufer Peretz A, Greenberg D, Wendlandt R, Shemer Avni Y, Newes-Adeyi G, Gofer I, Leventer-Roberts M, Davidovitch N, Rosenthal A, Gur-Arie R, Hertz T, Glatman-Freedman A, Monto AS, Azziz-Baumgartner E, Morris Ferdinands J, Toth Martin E, Malosh RE, Manuel Neyra Quijandría J, Levine M, Campbell W, Balicer R, Thompson MC, SHIRI workgroup. Study of Healthcare Personnel with Influenza and other Respiratory Viruses in Israel (SHIRI): study protocol. BMC Infectious Diseases, 2018. 18(1): p. 550.
Low M, Almog R, Balicer RD, Liberman N, Raz R, Peretz A, Nitzan O. Infectious disease burden and antibiotic prescribing in primary care in Israel. Annals of Clinical Microbiology and Antimicrobials, 2018. 17(1): p. 26.
Abelson S, Collord G, Ng SWK, Weissbrod O, Mendelson Cohen N, Niemeyer E, Barda N, Zuzarte PC, Heisler L, Sundaravadanam Y, Luben R, Hayat S, Wang TT, Zhao A, Cirlan I, Pugh RJ, Soave D, Ng K, Latimer C, Hardy C, Raine K, Jones D, Hoult D, Britten A, McPherson JD, Johansson M, Mbabaali F, Eagles J, Miller JK, Pasternack D, Timms L, Krzyzanowski P, Awadalla P, Costa R, Segal E, Bratman SV, Beer P, Behjati S, Martincorena I, Wang JCY, Bowles KM, Quirós JR, Karakatsani A, La Vecchia C, Trichopoulou A, Salamanca-Fernández E, Huerta JM, Barricarte A, Travis RC, Tumino R, Masala G, Boeing H, Panico S, Kaaks R, Krämer A, Sieri S, Riboli E, Vineis P, Foll M, McKay J, Polidoro S, Sala N, Khaw KT, Vermeulen R, Campbell PJ, Papaemmanuil E, Minden MD, Tanay A, Balicer RD, Wareham NJ, Gerstung M, Dick JE, Brennan P, Vassiliou GS, Shlush LI. Prediction of acute myeloid leukaemia risk in healthy individuals. Nature, 2018. 559: pp. 400–404.

Question 10

2017

Accepted Answer

Shadmi E, Low M, Balicer R, Steinman M. IMPACT OF A NURSE-BASED INTERVENTION ON MEDICATION OUTCOMES IN OLDER ADULTS: THE CC-MAP STUDY. Innovation in Aging, 2017. 1(Suppl 1): p. 80.
Shmueli L, Davidovitch N, Pliskin JS, Balicer RD, Hekselman I, Greenfield G. Seeking a second medical opinion: composition, reasons and perceived outcomes in Israel. Israel Journal of Health Policy Research, 2017. 6: p. 67.
Levine H, Prais D, Raviv Y, Rusanov V, Rosengarten D, Saute M, Hoshen M, Mussaffi H, Blau H, Kramer MR. Lung Transplantation in Cystic Fibrosis Patients in Israel: The Importance of Ethnicity and Nutritional Status. Clinical Transplantation, 2017. 31(11).
Benis A and Hoshen M. DisEpi: Compact Visualization as a Tool for Applied Epidemiological Research. Studies in Health Technology and Informatics, 2017. 244(The Practice of Patient Centered Care: Empowering and Engaging Patients in the Digital Era): pp. 38-42.
Benis A, Harel N, Barkan R, Sela T, Feldman B. Identification and Description of Healthcare Customer Communication Patterns Among Individuals with Diabetes in Clalit Health Services: A Retrospective Database Study. Studies in Health Technology and Informatics, 2017. 244(The Practice of Patient Centered Care: Empowering and Engaging Patients in the Digital Era): pp. 18-22.
Agay N, Flaks-Manov N, Nitzan U, Hoshen MB, Levkovitz Y, Munitz H. Cancer prevalence in Israeli men and women with schizophrenia. Psychiatry Research, 2017. 258: pp. 262-267.
Krivoy A, Stubbs B, Balicer RD, Weizman S, Feldman B, Hoshen M, Zalsman G, Hochman E, Shoval G. Low adherence to antidepressants is associated with increased mortality following stroke: A large nationally representative cohort study. European Neuropsychopharmacology, 2017. 27(10): pp. 970-976.
Shoval G, Stubbs B, Balicer RD, Feldman B, Hoshen M, Zalsman G, Sagy R, Hochman E, Weizman A, Krivoy A. Low adherence to antidepressants is associated with increased mortality in Parkinson disease patients. Parkinsonism & Related Disorders, 2017. 43: pp. 92-96.
Steinman MA, Low M, Balicer RD, Shadmi E. Epidemic Use of Benzodiazepines among Older Adults in Israel: Epidemiology and Leverage Points for Improvement. Journal of General Internal Medicine, 2017. 32(8): pp. 891-899.
Mei-Zahav M, Blau H, Hoshen M, Zvulunov A, Mussaffi H, Prais D, Stafler P, Steuer G, Lapidoth M, Amitai DB. Propranolol treatment for infantile hemangioma does not increase risk of childhood wheezing. Pediatric Pulmonology, 2017. 52(8): pp. 1071-1075.
Cohen-Mansfield J, Skornick-Bouchbinder M, Hoshen M, Brill S. The relationship between health services standardized costs and mortality is non-linear: Results from a large HMO population. Health Policy, 2017. 121(9): pp. 1008-1014.
Leventer-Roberts M, Hammerman A, Brufman I, Hoshen M, Braun M, Ashur Y, Lieberman N, Balicer R. Effectiveness of dasabuvir/ombitasvir/paritaprevir/ritonavir for hepatitis C virus in clinical practice: A population-based observational study. PLOS One, 2017. 12(7): e0176858.
Interator H, Lebenthal Y,  Hoshen M, Safra I, Balicer R, Leshno M, Shamir R. Distinct lipoprotein curves in normal weight, overweight and obese children and adolescents. Journal of Pediatric Gastroenterology & Nutrition, 2017. 65(6): pp. 673-680.
Reges O, Leibowitz M, Hoshen M, Leventer-Roberts M, Greenland P, Balicer R. Diabetes control: Incidence of acute myocardial infarction and all-cause mortality among patients with 3-6 years’ disease duration. European Journal of Preventive Cardiology, 2017. 24(10): pp. 1083-1092.
Balicer RD and Afek A. Digital health nation: Israel’s global big data innovation hub. Lancet, 2017. 389(10088): pp. 2451-2453.
Stafler P, Weinreb S, Mussaffi H, Mei-Zahav M, Prais D, Steuer G, Bar-On O, Hoshen M, Blau H. Feasibility of multiple breath washout measurements in infants with bronchiolitis: A pilot study. Pediatric Pulmonology, 2017. 52(6): pp. 763-770.
Spitzer-Shohat S, Shadmi E, Goldfracht M, Kay C, Hoshen M, Balicer RD. Reducing inequity in primary care clinics treating low socioeconomic Jewish and Arab populations in Israel. Journal of Public Health, 2017. 39(2): pp. 395-402.
Leibowitz M, Cohen-Stavi C, Basu S, Balicer R. Targeting LDL Cholesterol: Beyond Absolute Goals Toward Personalized Risk. Current Cardiology Reports, 2017. 19(6): p. 52
Srulovici E, Key C, Rotem M, Golfenshtein N, Balicer RD, Shadmi E. Diabetes Conversation MapTM and health outcomes: A systematic literature review. International Journal of Nursing studies. International Journal of Nursing Studies, 2017. 70: pp. 99-109.
Dagan N, Cohen-Stavi C, Leventer-Roberts M, Balicer RD. External validation and comparison of three prediction tools for risk of osteoporotic fractures using data from population based electronic health records: retrospective cohort study. BMJ, 2017. 356: i6755.
Eisen A, Haim M, Hoshen M, Balicer RD, Reges O, Leibowitz M, Iakobishvili Z, Hasdai D. Estimated glomerular filtration rate within the normal or mildly impaired range and incident non-valvular atrial fibrillation: Results from a population-based cohort study. European Journal of Preventive Cardiology, 2017. 24(2): pp. 213-222.
Cohen HA, Hoshen M, Gur S, Bahir A, Laks Y, Blau H. Efficacy and tolerability of a polysaccharide-resin-honey based cough syrup as compared to carbocysteine syrup for children with colds: a randomized, single-blinded, multicenter study. World Journal of Pediatrics, 2017. 13(1): pp. 27-33.

Question 11

2016

Accepted Answer

Cohen HA, Hoshen M, Gur S, Bahir A, Laks Y, Blau H. Seasonality of Methylphenidate Administration among Children in Israel. The Israel Medical Association Journal, 2016. 18: pp. 655–60.
Leibowitz M, Karpati T, Cohen-Stavi CJ, Feldman BS, Hoshen M, Bitterman H, Suissa S, Balicer RD. Association Between Achieved Low-Density Lipoprotein Levels and Major Adverse Cardiac Events in Patients with Stable Ischemic Heart Disease Taking Statin Treatment. JAMA Internal Medicine, 2016. 176(8): pp. 1105-13.
Dankner R, Boffetta P, Keinan-Boker L, Balicer RD, Berlin A, Olmer L, Murad H, Silverman B, Hoshen M, Freedman LS. Diabetes, prostate cancer screening, and risk of low- and high-grade prostate cancer: an 11 year historical population follow-up study of more than 1 million men. Diabetologia, 2016. 59(8): pp. 1683-91.
Dicker D, Feldman BS, Leventer-Roberts M, Benis A. Obesity or smoking: Which factor contributes more to the incidence of myocardial infarction? European Journal of Internal Medicine, 2016. 32: pp. 43-6.
Tonkikh O, Shadmi E, Flaks-Manov N, Hoshen M, Balicer RD2, Zisberg A. Functional status before and during acute hospitalisation and readmission risk identification. Journal of Hospital Medicine, 2016. 11(9): pp. 636-41.
Krivoy A, Balicer RD, Feldman B, Hoshen M, Zalsman G, Weizman A, Shoval G. Adherence to antidepressants is associated with lower mortality: a four-year population-based cohort study. The Journal of Clinical Psychiatry, 2016. 77(5): pp. e566-72.
Hoshen MB, Benis A, Keyes KM, Zoëga H. Stimulant use for ADHD and relative age in class among children in Israel. Pharmacoepidemiology Drug Safety, 2016. 25(6): pp. 652-60.
Levine H, Cohen-Cymberknoh M, Klein N, Hoshen M, Mussaffi H, Stafler P, Breuer O, Kerem E, Blau H. Reversible airway obstruction in cystic fibrosis: Common, but not associated with characteristics of asthma. Journal of Cystic Fibrosis, 2016. 15(5): pp. 652-9.
Ciobotaro P, Flaks-Manov N, Oved M, Schattner A, Hoshen M, Ben-Yosef E, Balicer RD, Zimhony O. Predictors of persistent carbapenem-resistant enterobacteriacea carriage upon readmission and score development. Infection Control and Hospital Epidemiology, 2016. 1: pp. 1-9.
Flaks-Manov N, Shadmi E, Hoshen M, Balicer RD. Health information exchange systems and length of stay in readmissions to a different hospital. Journal of Hospital Medicine, 2016. 11(6): pp. 401-6.
Jaffe DH, Flaks-Manov N, Benis A, Gabay H, DiBonaventura M, Rosenbaum H, Joseph A, Leventer-Roberts M. A population-based cohort of Gaucher disease patients identified using EHR data. BMJ Open, 2016. 19(7): p. A578.
Dankner R, Boffetta P, Balicer RD, Keinan Boker L, Sadeh M, Berlin A, Olmer L, Goldfracht M, Freedman LS. Time-Dependent Risk of Cancer After a Diabetes Diagnosis in a Cohort of 2.3 Million Adults. American Journal of Epidemiology, 2016. 183(12): pp. 1098-1106.

Question 12

2015

Accepted Answer

Krivoy A, Balicer RD, Feldman B, Hoshen M, Zalsman G, Weizman A, Shoval G. Adherence to antidepressant therapy and mortality rates in ischaemic heart disease: cohort study. The British Journal of Psychiatry, 2015. 206(4): pp. 297-301.
Reges O, Vilchinsky N, Leibowitz M, Khaskia A, Mosseri M, Kark JD. Change in health behaviours following acute coronary syndrome: Arab-Jewish differences. European Journal of Preventive Cardiology, 2015. 22(4): pp. 458-67.
Leventer-Roberts M, Feldman BS, Brufman I, Cohen-Stavi C, Hoshen M, Balicer RD. Effectiveness of 23-valent pneumococcal polysaccharide vaccine against invasive disease and hospital-treated pneumonia among people aged ≥65 years: a retrospective case-control study. Clinical Infectious Diseases, 2015. 60(10): pp. 1472-80.
Eisen A, Hoshen M, Balicer RD, Reges O, Rabi Y, Leibowitz M, Iakobishvili Z, Hasdai D. Estimated glomerular filtration rate within the normal or mildly impaired range and incident cardiovascular disease. The American Journal of Medicine, 2015. 128(9): pp. 1015-22.
Cohen CJ, Flaks-Manov N, Low M, Balicer RD, Shadmi E. High-risk case identification for use in comprehensive complex care management. Population Health Management, 2015. 18(1): pp. 15-22.
Henig O, Weber G, Hoshen MB, Paul M, German L, Neuberger A, Gluzman I, Berlin A, Shapira C, Balicer RD. Risk factors for and impact of carbapenem-resistant Acinetobacter baumannii colonization and infection: matched case-control study. European Journal of Clinical Microbiology Infect Dis, 2015. 34(10): pp. 2063-8.
Shadmi E, Flaks-Manov N, Hoshen M, Goldman O, Bitterman H, Balicer RD. Predicting 30-day readmissions with preadmission electronic health record data. Medical Care, 2015. 53(3): pp. 283-9.
Haim M, Hoshen M, Reges O, Rabi Y, Balicer R, Leibowitz M. Prospective national study of the prevalence, incidence, management and outcome of a large contemporary cohort of patients with incident non-valvular atrial fibrillation. Journal of the American Heart Association, 2015. 4(1): p. e001486.
Balicer RD, Hoshen M, Cohen-Stavi C, Shohat-Spitzer S, Kay C, Bitterman H, Lieberman N, Jacobson O, Shadmi E. Sustained reduction in health disparities achieved through targeted quality improvement: one-year follow-up on a three-year intervention. Health Services Research Journal, 2015. 50(6): pp. 1891-909.
Krivoy A, Balicer RD, Feldman B, Hoshen M, Zalsman G, Weizman A, Shoval G. The impact of age and gender on adherence to antidepressants: a 4-year population-based cohort study. Psychopharmacology (Berl), 2015. 232(18): pp. 3385-90.
Cahn A, Raz I, Kleinman Y, Balicer R, Hoshen M Lieberman N, Brenig N, Del Prato S, Cefalu W. Clinical assessment of individualized glycemic goals in patients with type 2 diabetes: formulation of an algorithm based on a survey amongst leading worldwide diabetologists. Diabetes Care, 2015. 38(12): pp. 2293-300.

Question 13

2014

Accepted Answer

Yamin D, Gavious A, Solnik E, Davidovitch N, Balicer RD, Galvani AP, Pliskin JS. An innovative influenza vaccination policy: targeting last season’s patients. PLoS Computational Biology, 2014. 10(5): p. e1003643.
Yamin D, Balicer RD, Galvani AP. Cost-effectiveness of influenza vaccination in prior pneumonia patients in Israel. Vaccine, 2014. 32(33): pp. 4198-205.
Feldman BS, Cohen-Stavi CJ, Leibowitz M, Hoshen MB, Singer SR, Bitterman H, Lieberman N, Balicer RD. Defining the role of medication adherence in poor glycemic control among a general adult population with diabetes. PLoS One, 2014. 9(9): p. e108145.
Balicer RD, Cohen CJ, Leibowitz M, Feldman BS, Brufman I, Roberts C, Hoshen M. Pneumococcal vaccine targeting strategy for older adults: customized risk profiling. Vaccine, 2014. 32(8): pp. 990-5.
Reges O, Leibowitz M, Hoshen M, Rabi Y, Gluzman I, Cohen CJ, Balicer RD. Reduction in myocardial infarction incidence: focus on socioeconomic disparities. International Journal of Cardiology, 2014. 174(3): pp. 773-4.
Cohen HA, Blau H, Hoshen M, Batat E, Balicer RD. Seasonality of asthma: a retrospective population study. Pediatrics, 2014. 133(4): pp. e923-32.
Gavrielov-Yusim N, Hoshen M, Singer SR, Neumann L, Balicer RD. The weight of MMRV-related febrile convulsions among other clinical factors contributing to febrile convulsions in children. Vaccine, 2014. 32(39): pp. 4954-9.
Karpati T, Cohen-Stavi C, Leibowitz M, Hoshen M, Feldman BS, Balicer RD. Towards a subsiding diabetes epidemic: trends from a large population-based study in Israel. Population Health Metrics, 2014. 12(1): p. 32.
Chowdhury R, Kunutsor S, Vitezova A, Oliver-Williams C, Chowdhury S, Kiefte-de-Jong JC, Khan H, Baena CP, Prabhakaran D, Hoshen MB, Feldman BS, Pan A, Johnson L, Crowe F, Hu FB, Franco OH. Vitamin D and risk of cause specific death: systematic review and meta-analysis of observational cohort and randomised intervention studies. BMJ, 2014. 348: p. g1903.
Confino-Cohen R, Brufman I, Goldberg A, Feldman BS. Vitamin D, asthma prevalence and asthma exacerbations: a large adult population-based study. Allergy, 2014. 69(12): pp. 1673-80.

Question 14

2013

Accepted Answer

Tsur A, Feldman BS, Feldhammer I, Hoshen MB, Leibowitz G, Balicer RD. Decreased serum concentrations of 25-hydroxycholecalciferol are associated with increased risk of progression to impaired fasting glucose and diabetes. Diabetes Care, 2013. 36(5): pp. 1361-7.
Balicer RD, Shadmi E, Israeli A. Interventions for reducing readmissions – are we barking up the right tree? Israel Journal of Health Policy Research, 2013. 2(1): p. 2.
Low M, Nitzan O, Bitterman H, Cohen C, Hammerman A, Lieberman N, Raz R, Balicer RD. Trends in outpatient antibiotic use in Israel during the years 2000-2010: setting targets for an intervention. Infection, 2013. 41(2): pp. 401-7.
Dror Y, Giveon SM, Hoshen M, Feldhamer I, Balicer RD, Feldman BS. Vitamin D levels for preventing acute coronary syndrome and mortality: evidence of a nonlinear association. The Journal of Clinical Endocrinology and Metabolism, 2013. 98(5): pp. 2160-7.

Question 15

2012

Accepted Answer

Gavrielov-Yusim N, Battat E, Neumann L, Friger M, Balicer RD. Birth order and private voluntary immunization–a study of 110,902 children. Vaccine, 2012. 30(2): pp. 442-7.
Balicer R, Bitterman H, Shadmi E. Multiple chronic conditions and morbidity burden: challenges and considerations for an organizational strategy. Harefuah, 2012. 151(7): pp. 388-92, 437.
Singer SR, Hoshen M, Shadmi E, Leibowitz M, Flaks-Manov N, Bitterman H, Balicer RD. EMR-based medication adherence metric markedly enhances identification of nonadherent patients. American Journal of Managed Care, 2012. 18(10): pp. e372-7.

Question 16

2011

Accepted Answer

Balicer RD, Shadmi E, Lieberman N, Greenberg-Dotan S, Goldfracht M, Jana L, Cohen AD, Regev-Rosenberg S, Jacobson O. Reducing health disparities: strategy planning and implementation in Israel’s largest health care organization. Health Services Research Journal, 2011. 46(4): pp. 1281-99.

Publications

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